Plasma concentration-time profiles of sEH inhibitors with varied non-polar group (R1) after an oral dose of 0.3 mg/kg body weight. (a) Alkyl acid and derivatives (AUDA series) (● 1, ○ 8, and ▼ 12). (b) Cyclohexyl ether linker with cis-ether polar group and para-fluorophenyl R2 group (● 36, ○ 44, ▼ 48, and Δ 47). (c) Piperidyl linker with a sulfonamide group (● 17, ○ 27, and ▼ 32). Each curve represents data from one dog (n = 1).