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. Author manuscript; available in PMC: 2012 Feb 23.
Published in final edited form as: Eur J Pharm Sci. 2010 Mar 30;40(3):222–238. doi: 10.1016/j.ejps.2010.03.018

Fig. 3.

Fig. 3

Plasma concentration-time profiles of sEH inhibitors with piperidyl linker after an oral dose of 0.3 mg/kgbody weight (n = 1). (a) Primary pharmacophore of urea (■ 14) or amide group (□ 72). (b) Urea with adamantyl R1 group, a piperidyl linker and amides with varying chain lengths (● 14, ○ 15, and ▼ 19). (c) Urea with 4-trifluoromethoxyphenyl R1 group, a piperidyl linker and amides with varying chain lengths (● 24(CH3), ○ 25(C2H5), and ▼ 26(C3H7)). Each curve represents data from one dog (n = 1).