Plasma concentration-time profiles of sEH inhibitors with piperidyl linker after an oral dose of 0.3 mg/kgbody weight (n = 1). (a) Primary pharmacophore of urea (■ 14) or amide group (□ 72). (b) Urea with adamantyl R1 group, a piperidyl linker and amides with varying chain lengths (● 14, ○ 15, and ▼ 19). (c) Urea with 4-trifluoromethoxyphenyl R1 group, a piperidyl linker and amides with varying chain lengths (● 24(CH3), ○ 25(C2H5), and ▼ 26(C3H7)). Each curve represents data from one dog (n = 1).