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. Author manuscript; available in PMC: 2012 Feb 23.
Published in final edited form as: Eur J Pharm Sci. 2010 Mar 30;40(3):222–238. doi: 10.1016/j.ejps.2010.03.018

Table 3.

Inhibitory potency with sEH of different species

Acronymd Enzyme CMNPC t-DPPO
Humana Mousea Rata Humanb Dogc
Structure IC50
1 AUDA graphic file with name nihms203825t13.jpg 3 10 11 10 3
3 AEPU graphic file with name nihms203825t14.jpg 14 3 5 45 86
14 APAU graphic file with name nihms203825t15.jpg 15 9 6 300 500
24 TPAU graphic file with name nihms203825t16.jpg 12 97 79 160 9300
27 TUPS graphic file with name nihms203825t17.jpg 3 5 9 26 3200
31 CPAU graphic file with name nihms203825t18.jpg 28 12 7 300 930
39 t-AUCB graphic file with name nihms203825t19.jpg 2 8 8 2 1
40 c-AUCB graphic file with name nihms203825t20.jpg 1 4 7 1 1
45 c-TUCB graphic file with name nihms203825t21.jpg 1 4 6 1 4
62 AUSM graphic file with name nihms203825t22.jpg 3 10 8 6 31
a

measured with purified recombinant enzyme at protein concentration of 0.012 μg/ml.

b

measured with purified recombinant enzyme at protein concentration of 0.12 μg/ml.

c

measured with liver cytosolic preparation at protein concentration of 0.2 mg/ml.

d

acronym commonly used in the literature. AUDA, 12-(3-adamantane-1-yl-ureido)- dodecanoic acid; AEPU, 1-adamantan-1-yl-3-{5-[2-(2- ethoxyethoxy)ethoxy]pentyl}urea; APAU, N-(1-acetylpiperidin-4-yl)-N’-(adamant-1-yl) urea; TPAU, 1-trifluoromethoxyphenyl-3-(1-acetylpiperidin-4-yl) urea; TUPS, 1-(1-methylsulfonyl-piperidin-4-yl)-3-(4-trifluoromethoxy-phenyl)-urea; CPAU, 1-cycloheptyl-3-(1-acetylpiperidin-4-yl) urea; t-AUCB, trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid; c-AUCB, cis-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid; c-TUCB, cis-4-[4-(3-trifluoromethoxyphenyl-l-ureido)-cyclohexyloxy]-benzoic acid ; AUSM, 4-(3-adamantane-1-yl-ureido)-2-hydroxyl-benzoic acid methyl ester.