Table 5.
Compartmental pharmacokinetic parameters of sEHIs after oral gavage at a 0.3 mg/kgdose in dogs (n = 3)
| # | Acronym | Compartment | Correlation | Tmaxa (h) | Cmaxb (μM) | T1/2c (h) | AUCd (μM*min) | Bioavailabilitye (%) |
|---|---|---|---|---|---|---|---|---|
| 3 | AEPU | 1 | 0.99 ± 0.01 | 0.2 ± 0.1 | 0.02 ± 0.01 | 1.7 ± 1.0 | 1.8 ± 0.6 | 21 ± 4 |
| 14 | APAU | 1 | 0.98 ± 0.01 | 1.0 ± 0.7 | 0.08 ± 0.03 | 1.7 ± 0.4 | 14 ± 1 | 64 ± 14 |
| 39 | t-AUCB | 1 | 0.96 ± 0.04 | 7.3 ± 5.4 | 0.15 ± 0.03 | 12 ± 10 | 270 ± 100 | 100 ± 30f |
a
time of maximum concentration.
b
maximum concentration.
c
terminal half life.
d
area under the concentration (Time0-24 h).
e
bioavailability=([AUC]p.o./Dose)/([AUC]i.v./Dose).
f
the bioavailability of t-AUCB was calculated using [AUC]0-24 due to the long beta phase half life.