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. Author manuscript; available in PMC: 2012 Feb 23.
Published in final edited form as: J Med Chem. 2010 Oct 14;53(19):7067–7075. doi: 10.1021/jm100691c

Figure 1.

Figure 1

The soluble epoxide hydrolase inhibitor 52 (sEHi) reduces local inflammatory pain at a far lower dose than morphine. The inflammatory agent carrageenan was administered at time 0 resulting in a stable hyperalgesic response for the duration of the experiment. Zero time points represent normal response to pain. Treatment at 180 minutes post carrageenan with either morphine or compound 52 reversed symptoms. Standard deviation represents the average of 6 animals with regard to mechanical withdrawal threshold.