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Synthesis of N-acyl and N-sulfonyl piperidine analogues
Reagents and conditions: (a) 1-BOC-4-aminopiperidine, THF, 0 °C to rt, 12h; (b) 1N HCl in MeOH, reflux, 3h; (c) R1SO2Cl, Et3N, THF, 0 °C to rt, 12h; (d) EDCI, R2COOH, DMAP, DCM, rt, 12-24h.
