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. Author manuscript; available in PMC: 2012 Feb 23.

Published in final edited form as: J Med Chem. 2010 Oct 14;53(19):7067–7075. doi: 10.1021/jm100691c

Table 2.

Substituted phenyl analogues


		IC₅₀ (nM)

Compd	R	Human	Murine	logP (±0.5)
10		1,700	>5,000	1.6
11		40	8.7	1.8
12		43	55	1.8
13		8.3	1.3	2.3
14		2.8	3.3	2.8
15		87	8.7	1.0
16		3.5	0.4	2.8
17		61	100	1.1
18		>5,000	>5,000	0.8
19		2,000	650	0.2
20		38	97	1.7
21		140	64	1.6
22		330	1,000	0.4
23		406	1,400	0.0