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. Author manuscript; available in PMC: 2012 Feb 23.
Published in final edited form as: J Med Chem. 2010 Oct 14;53(19):7067–7075. doi: 10.1021/jm100691c

Table 3.

Halophenyl urea analogues

graphic file with name nihms233914u1.jpg
IC50 (nM)
Compd R Human Murine logP (±0.5)
24 graphic file with name nihms233914t23.jpg 79 110 1.4
25 graphic file with name nihms233914t24.jpg 10 23 2.2
26 graphic file with name nihms233914t25.jpg 3.6 15 2.4
27 graphic file with name nihms233914t26.jpg 7.2 1.4 2.5
28 graphic file with name nihms233914t27.jpg 39 20 1.7
29 graphic file with name nihms233914t28.jpg 300 780 1.6
30 graphic file with name nihms233914t29.jpg 21 6.6 2.2
31 graphic file with name nihms233914t30.jpg 1100 2900 2.0
32 graphic file with name nihms233914t31.jpg 3.4 0.6 2.9
33 graphic file with name nihms233914t32.jpg 0.4 1.0 3.3
34 graphic file with name nihms233914t33.jpg >5,000 >5,000 1.3
35 graphic file with name nihms233914t34.jpg 4.1 2.3 3.0
36 graphic file with name nihms233914t35.jpg 0.7 6.5 2.4
37 graphic file with name nihms233914t36.jpg 17 8.8 2.4
38 graphic file with name nihms233914t37.jpg 0.4 0.7 3.5
39 graphic file with name nihms233914t38.jpg 17 28 3.8
40 graphic file with name nihms233914t39.jpg 3.7 2.8 2.5