Table 4.
| ||||
---|---|---|---|---|
IC50 (nM) | ||||
Compd | R2 | Human | Murine | logP (±0.5) |
47 | 0.7 | 1.3 | 2.4 | |
48 | 0.6 | 0.7 | 2.9 | |
49 | 3.1 | 5.0 | 2.6 | |
50 | 1.5 | 18 | 3.8 | |
51 | 0.5 | 1.2 | 2.4 | |
52 | 0.4 | 0.4 | 2.7 | |
53 | 0.4 | 0.4 | 3.1 | |
54 | 0.5 | 2.7 | 2.0 | |
55 | 2.9 | 2.0 | 2.2 | |
56 | 0.4 | 0.7 | 2.6 | |
57 | 1.8 | 0.4 | 3.1 | |
58 | 0.4 | 0.4 | 3.5 | |
59 | 0.8 | nda | 4.3 |
nd = Not determined