Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2012 Feb 23.

Published in final edited form as: J Med Chem. 2010 Oct 14;53(19):7067–7075. doi: 10.1021/jm100691c

Table 4.

N-Acyl and N-sulfonyl piperidine analogues


		IC₅₀ (nM)

Compd	R²	Human	Murine	logP (±0.5)
47		0.7	1.3	2.4
48		0.6	0.7	2.9
49		3.1	5.0	2.6
50		1.5	18	3.8
51		0.5	1.2	2.4
52		0.4	0.4	2.7
53		0.4	0.4	3.1
54		0.5	2.7	2.0
55		2.9	2.0	2.2
56		0.4	0.7	2.6
57		1.8	0.4	3.1
58		0.4	0.4	3.5
59		0.8	nd^a	4.3

^a

nd = Not determined