Table 5.

Pharmacokinetic Screening Results^a

Compound	Cmax (nM)	Tmax (min)	t1/2 (min)	AUCt (×104nM·min)
AUDAb	14	80	126	0.3
2	138	45	78	1.9
3	2,770	60	50	35
4	4,600	50	56	58
12	5,570	30	72	92
13	4,810	30	56	74
14	5,860	50	58	95
15	13,000	70	82	283
24	8,410	83	378	467
25	18,300	188	381	1,360
27	3,790	440	881	375
35	5,940	230	814	516
40	17400	220	980	1400
52	8900	190	1180	985

^aValues are from single oral cassette dosing at 5 mg/kg in 120-150 μl of 20% PEG400 v/v in oleic ester rich triglyceride

^bFull pharmacokinetic profiles are shown in Figures S1 – S3 and plots of murine AUC as a function of the IC₅₀ on the human enzyme and the murine enzyme are shown if Figures S4 and S5 in the supplementary material.

^cAUDA gave biphasic kinetics