A, worldwide incidence and distribution of HPV-associated cancers (data from ref. 1). Red, HPV-positive cancer; white, HPV-negative cancer. B, incidence and distribution of HPV-associated cancers in the U.S. (data from refs. 3 and 4). The approximate percentage of HPV-associated cancer attributable to HPV16 and -18 is also shown. Red, HPV-positive cancer; white, HPV-negative cancer.