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The nonmyeloablative preparative regimen used clinically was similar to that used for mice and monkeys, except for the use of cytoxan rather than low-dose whole-body irradiation for myelodepletion prior to bone marrow administration. For HLA antigen–mismatched patients, T-cell depletion was effected with an anti-CD2 monoclonal antibody. ITN indicates Immune Tolerance Network; T1, thymic irradiation. To convert centigray to rad, multiply by 100.
