TABLE 1.
Bladder pressure (cm H2O) |
Euthanization FES/bladder pressure |
Fluorogold tracing |
|||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dog | Surgery |
BDNF cuff (left only) |
Post op. day |
Left | Right | Both |
Electrode lead removal Post op. day |
Post op. day |
Left | Right | Both | Left | Right |
1 | Sham | None | 62 | 33.8 | 11.0 | 33.9 | 126 | 126 | 29.6 | 6.7 | 41.9 | + | + |
2 | Sham | Saline | 91 | 0.0 | 0.0 | 0.0 | 113 | 394 | 3.9 | 5.2 | 4.9 | + | + |
3 | Sham | Saline | 84 | 10.6 | 0.0 | 5.3 | 147 | 394 | 16.4 | 11.1 | 10.3 | + | + |
4 | Sham | Saline | a | 57 | 366 | 0.0 | 0.0 | 0.0 | + | + | |||
5 | Transect only | None | b | 233 | − | − | |||||||
6 | Transect-repair | None | 92 | 0 | 0 | 0 | 116 | 125 | 0 | 0 | 0 | + | + |
7 | Transect-repair | None | a | 12 | 49 | + | + | ||||||
8 | Transect-repair | 0.5 g/mL | 84 | 0.0 | 0.0 | 0.0 | 91 | 149 | 0.0 | 4.9 | 5.4 | + | + |
9 | Transect-repair | 0.5 g/mL | 83 | 0.0 | 0.0 | 0.0 | 174 | 365 | 0.0 | 0.0 | 0.0 | + | + |
10 | Transect-repair | 0.5 g/mL | 78 | 0.0 | 0.0 | 0.0 | 80 | 373 | 0.0 | 19.6 | 17.2 | + | + |
11 | Transect-repair | 0.5 g/mL | 118 | 0.0 | 1.8 | 1.1 | 335 | 335 | 0.0 | 1.7 | 2.0 | + | + |
12 | Transect-repair | 5.0 g/mL | 84 | 0.0 | 0.0 | 0.0 | 167 | 366 | 0.0 | 0.0 | 0.0 | − | + |
13 | Transect-repair | 5.0 g/mL | 84 | 0.0 | 0.0 | 0.0 | 290 | 366 | 0.0 | 0.0 | 0.0 | + | + |
14 | Transect-repair | 5.0 g/mL | 297 | 0.0 | 1.0 | 1.1 | 365 | 365 | 0.0 | 5.6 | 5.0 | + | + |
15 | Transect-repair | 5.0 g/mL | 78 | 0.0 | 0.0 | 0.0 | 265 | 366 | 0.0 | 13.1 | 11.6 | + | + |
Electrode leads exiting the skin became damaged prior to the first FES testing.
Electrodes were not implanted in the nerve transection only control animal.
BDNF, brain-derived neurotrophic factor; FES, functional electrical stimulation; post op., post-operative; transect-repair, nerve transection and immediate repair.