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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: J Med Primatol. 2010 Nov 2;40(2):120–128. doi: 10.1111/j.1600-0684.2010.00454.x

Fig. 3.

Fig. 3

(A) Intravenous inoculation of SHIV-1157ipEL: monkey REk-11 was inoculated i.v. with 10 ml of PBMC-grown virus. This was followed by rapid passage at peak viremia (week 2 post-inoculation) through three additional RM using serial blood transfer (10 ml each). Viral RNA (vRNA) levels were measured at time points indicated. (B) Intrarectal inoculation of SHIV-1157ipEL-p in six monkeys, using limited weekly low-dose inoculations (maximally five). RM RZb-11 remained uninfected at week 2 after the fifth exposure and was given a single high-dose of SHIV-1157ipEL-p. vRNA levels were measured at the time points indicated. The horizontal dotted line indicates the lower limit of detection (<50 vRNA copies/ml). (C) Absolute CD4+ T-cell counts of RM infected with SHIV-1157ipEL-p. SHIV, simian–human immunodeficiency virus; RM, rhesus macaques; PBMC, peripheral blood mononuclear cells.