Table 3.
Neutralization titers of sera from SHIV-1157ipEL-p-challenged rhesus macaques
| Titers (plasma dilution at 50% neutralization in TZM-bl cells) | |||||
|---|---|---|---|---|---|
| Homologous clade C (tier 1) | Heterologous clade C | Heterologous clade B | |||
| Animal no. | SHIV-1157ipEL-p | SHIV-2873Nip (tier 2) | MW965.5 (tier 1) | SHIV-Bo159N41 | SHIVSF162P4 |
| RBi-11 | 128 | <20 | 1498 | 49 | 83 |
| REk-11 | 3690 | <20 | >43,740 | 9640 | 7615 |
| RFa-11 | 1038 | <20 | 8019 | 160 | 271 |
| RGf-11 | 695 | <20 | 4753 | 55 | 335 |
| RIj-11 | 1985 | <20 | 24,586 | 220 | 348 |
| RKa-11 | 779 | <20 | 8415 | 707 | 353 |
| RQa-11 | 403 | <20 | 3589 | 71 | 198 |
| RZb-11 | 243 | <20 | 1571 | 58 | 92 |
SHIV, simian–human immunodeficiency virus.
1
This tier 1 R5 SHIV strain is of clade B origin and encodes extra NF-κB sites in the long terminal repeats (Siddappa et al., unpublished data).