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. Author manuscript; available in PMC: 2012 Feb 23.
Published in final edited form as: Magn Reson Med. 2011 May 23;66(5):1346–1352. doi: 10.1002/mrm.22928

FIG. 1.

FIG. 1

SIR pulse sequence with an FSE readout (SIR-FSE) and reduced TR. In this figure, ti is the inversion recovery (IR) time and td is the predelay (PD) time. A low-power inversion pulse (1-ms block pulse) inverts the free pool longitudinal magnetization, affecting the macromolecular pool to a lesser degree. The resulting observed recovery of free pool longitudinal magnetization can described by the biexponential function in Eq. 1. A total of 24 FSE echoes (NE) were acquired (ACQ) with an echo spacing (esp) of 5.9 ms during each TR period. Based on previous simulations (22), the longitudinal magnetization of both free and macromolecular pools can be assumed to be zero at the end of the FSE train. This assumption was used as the initial condition for the SIR-FSE signal equations (see Theory section for details).