Table 1.

PLINK TDT association results for the 15 significantly associated SNPs in the screening panel of affected sibling pair families.

Marker	Position	Gene	Minor Allele Frequency	Transmitted Minor Allele Count	Untransmitted Allele Count	TDT P-Value	Odds Ratio (95% CI)	rs2271189 Adjusted P-Value	rs11171747 Adjusted P-Value
rs773107	54655773	RAB5B	0.32	348	282	0.0086	1.23 (1.05 – 1.44)	0.8712	0.5505
rs1701704	54698754	Intergenic	0.34	358	286	0.0046	1.25 (1.07 – 1.46)	0.7606	0.4306
rs2456973	54703195	IKZ4	0.34	357	283	0.0034	1.26 (1.08 – 1.47)	0.7048	0.3831
ERBB3rsx29	54714511	IKZ4	0.09	134	99	0.0219	1.35 (1.04 – 1.76)	0.9678	0.5237
rs705704	54721679	Intergenic	0.34	264	196	0.0015	1.35 (1.12 – 1.62)	0.4748	0.2061
rs11171739	54756892	Intergenic	0.42	386	321	0.0145	1.20 (1.04 – 1.39)	0.2563	0.4860
rs2271194	54763961	ERBB3	0.42	378	314	0.0150	1.20 (1.04 – 1.40)	0.3413	0.6014
rs10876870	54764269	ERBB3	0.42	390	322	0.0108	1.21 (1.05 – 1.40)	0.2511	0.5115
ERBB3rsx44	54766741	ERBB3	0.09	127	93	0.0219	1.37 (1.05 – 1.78)	0.9782	0.4762
rs2292239	54768447	ERBB3	0.35	350	288	0.0141	1.22 (1.04 – 1.42)	0.8289	0.5070
rs705708	54775180	ERBB3	0.49	411	315	3.67×10−4	1.31 (1.13 – 1.51)	0.8417	0.2842
rs2292238	54780089	ERBB3	0.45	351	274	0.0021	1.28 (1.10 – 1.50)	0.0824	0.2518
rs2271189	54781258	ERBB3	0.43	388	282	4.22×10−5	1.38 (1.18 – 1.60)	1.0000	0.0721
rs11171747	54804675	Intergenic	0.36	278	374	1.70×10−4	0.74 (0.64 – 0.87)	0.1132	1.0000
rs7960225	54851077	SMARCC2	0.34	264	333	0.0047	0.79 (0.67 – 0.93)	0.1690	0.6075

Adjusted P-Values are calculated using the Main Effects option implemented in the program UNPHASED. SNPs denoted with ERBB3rsx represent novel SNPs identified in 1000 Genomes data, not present in dbSNP.