Table 1. Results of parameter exchange analysis.

	Airways	Alveoli
Epithelium Surface Area	+	−
Smooth Muscle Volume	−−−	++
Endothelium Area	−	+
Macrophage Volume	unaffected	unaffected
Immune Cells Volume	unaffected	unaffected
Interstitium Volume	−−	−
Mitochondria Volume	−−	+
Blood Flow Rate	unaffected	unaffected
Clearance	unaffected	−

Table indicates the direction in which the exposure (AUC) of MTR changes after IT instillation, upon exchanging the indicated parameter values between airway and alveoli. A plus indicates an increase, while a minus indicates a decrease in AUC relative to the baseline lung model parameters. One plus or minus sign corresponds to a 1.1 to 1.5 fold change in AUC; two plus or minus signs to a 1.5 to 2 fold change; and three plus or minus signs to a >5 fold change. For clearance, the parameter value was increased 10-fold.