Table 1. LRP6 rs2302685 frequency distribution in the separate cohort samples (Oxford, Leuven, Vienna).

		Overview groups				Overview ileal CD
			IBD			Gender		Disease behaviour			Age at diagnosis
Oxford		controls	UC	colonic CD (L2)	ileal CD (L1+L3)	male	female	B1	B2	B3	>17	</ = 17
	TT	470	416	89	238	90	134	33	109	82	207	31
Genotypes (n)	CT	242	185	53	123	50	71	18	54	49	102	21
	CC	24	33	4	16	8	8	2	4	10	11	5
samples (n)	all	736	634	146	377	148	213	53	167	141	320	57
	TT	63.86%	65.62%	60.96%	63.13%	60.81%	62.91%	62.26%	65.27%	58.16%	64.69%	54.39%
Genotypes	CT	32.88%	29.18%	36.30%	32.63%	33.78%	33.33%	33.96%	32.34%	34.75%	31.88%	36.84%
(frequency)	CC	3.26%	5.21%	2.74%	4.24%	5.41%	3.76%	3.77%	2.40%	7.09%	3.44%	8.77%
Allele	T	80.30%	80.21%	79.11%	79.44%	77.70%	79.58%	79.25%	81.44%	75.53%	80.63%	72.81%
Frequency	C	19.70%	19.79%	20.89%	20.56%	22.30%	20.42%	20.75%	18.56%	24.47%	19.38%	27.19%

The different distribution of genotypes is demonstrated for each group and subgroup: controls, ulcerative colitis (UC), Crohn's disease (CD) with solely colonic involvement (colonic CD; L2) and CD with solely ileal as well as ileal and colonic involvement (ileal CD; L1+L3). The ileal CD group was further sub-grouped according to gender, disease behaviour (inflammatory B1; stricturing B2; penetrating B3) and age at diagnosis (older than 17: >17; 17 and younger: </ = 17).