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. 2012 Feb 23;8(2):e1002554. doi: 10.1371/journal.ppat.1002554

Figure 1. Phylogenetic analysis of Plasmodium CDC20.

Figure 1

A. Amino-acid sequence of a Plasmodium berghei putative CDC20. WD repeats are shown in bold and underlined. Other motifs (highlighted) are the KEN box, RVL cyclin binding motif and IR motif. B. WD domains from various eukaryotic Cdc20 and Cdh1 homologues were aligned and used to draw a phylogenetic tree. The S. cerevisiae meiotic APC/C regulator (Ama1) was used as an out group. Four clusters are apparent. Two correspond to previously described Cdc20 and Cdh1 protein families. A third includes homologues from Trypanosomatidae species. The fourth cluster includes all the identified CDC20/CDH1 homologues from Plasmodium species.