Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Feb 23;7(2):e32008. doi: 10.1371/journal.pone.0032008

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

PMC Copyright notice

(A) G37R SOD1 NSC19 cells are more vulnerable to oxidative stress (H₂O₂ (5 mM) for 24 h) than are WT SOD1 NSC19 cells. Cell viability assessed by MTS assay shows 22% cell survival in WT SOD1 cells v.s. 5% survival in G37R SOD1 cells (n = 6, * p<0.05). (B) Ex-4 reduced cell membrane permeability and protected cells from serum deprivation in both WT SOD1- and G37R SOD1-expressing NSC19 cells. Cells were cultured in no-serum media for 48 h in the presence and absence of 100 nM Ex-4. Cell viability was assessed by LDH assay. LDH levels were significantly reduced by Ex-4 treatment in both cells, under conditions of either Ex-4 alone or Ex-4 plus no-serum stress (C: vehicle-treated control; Ex-4: exendin-4; no serum: serum deprivation, n = 5, * p<0.05).