Table 2.
Chemokine and chemokine receptor expression in acute GVHD.
| Chemokine | Expression in lymphoid tissues (weeks after transplant) | Expression in target organs (weeks after transplant) |
References | |||
|---|---|---|---|---|---|---|
| Spleen/lymph nodes | Intestine | Liver | Lung | Skin | ||
| CXCL1 | – | + (1–3, 6) | + (1, 2) | + (1, 2) | Bouazzaoui et al. (2009), Kittan and Hildebrandt (2010) | |
| CXCL2 | – | – | + (1) | + (1, 2) | Bouazzaoui et al. (2009), Kittan and Hildebrandt (2010) | |
| CXCL9 | + (1) | + (1–3, 6) | + (1–3) | + (1–3, 6) | + (1, 2) | Bouazzaoui et al. (2009), Kittan and Hildebrandt (2010), Wysocki et al. (2005) |
| CXCL10 | + (1) | + (1) | + (1–3) | + (1–3, 6) | + (1, 2) | Bouazzaoui et al. (2009), Kittan and Hildebrandt (2010), Wysocki et al. (2005) |
| CXCL11 | + (1) | + (1–3, 6) | + (1–3, 6) | + (1–3) | + (1, 2) | Bouazzaoui et al. (2009), Kittan and Hildebrandt (2010), Wysocki et al. (2005) |
| CXCL16 | + (3, 6) | + (1, 2, 3) | – | Bouazzaoui et al. (2009) | ||
| CCL2 | + (1) | + (1–3) | + (1–3) | + (1, 2) | + (1, 2) | Kittan and Hildebrandt (2010), Wysocki et al. (2005), Castor et al. (2011) |
| CCL3 | + (1) | + (1–3, 6) | + (1–3, 6) | + (1–3, 6) | Bouazzaoui et al. (2009), Wysocki et al. (2005), Castor et al. (2011), Serody et al. (1999) | |
| CCL4 | + (1) | – | + (1–3, 6) | + (1–3, 6) | Wysocki et al. (2005) | |
| CCL5 | + (1) | + (1, 2, 3) | + (1–3, 6) | + (1–3, 6) | + (1, 2) | Bouazzaoui et al. (2009), Wysocki et al. (2005), Castor et al. (2011), Choi et al. (2007) |
| CCL6 | + (1, 2) | Reiss et al. (2001) | ||||
| CCL7 | + (1, 2) | Reiss et al. (2001) | ||||
| CCL8 | – | – | + (1–3, 6) | + (1, 2) | Bouazzaoui et al. (2009) | |
| CCL9 | + (1, 2) | Kittan and Hildebrandt (2010) | ||||
| CCL11 | + (1, 2) | Kittan and Hildebrandt (2010) | ||||
| CCL12 | + (1–3) | + (1–3, 6) | + (1, 2) | Bouazzaoui et al. (2009), Kittan and Hildebrandt (2010) | ||
| CCL17 | + (2) | Wysocki et al. (2005) | ||||
| CCL19 | + (1) | + (1, 2) | Kittan and Hildebrandt (2010), Yakoub-Agha et al. (2006) | |||
| CCL20 | + (1, 2, 3) | + (1, 2, 3) | + (1, 2, 3) | Varona et al. (2006) | ||
| CCL21 | + (1) | Sasaki et al. (2003) | ||||
| CCL27 | + (1) | Reiss et al. (2001) | ||||
| XCL1 | + (1–3, 6) | + (1–3) | + (1–3, 6) | + (1, 2) | Bouazzaoui et al. (2009), Kittan and Hildebrandt (2010) | |
| CX3CL1 | + (1, 2) | Ueha et al. (2007) | ||||
| CHEMOKINE RECEPTORS | ||||||
| CXCR2 | – | + (2, 3) | – | Bouazzaoui et al. (2009) | ||
| CXCR3 | + (1) | + (1, 2, 6) | + (1) | + (1–3) | + (1, 2) | Bouazzaoui et al. (2009), Kittan and Hildebrandt (2010), Wysocki et al. (2005) |
| CXCR6 | + (1–3, 6) | + (1–3) | + (1–3, 6) | Bouazzaoui et al. (2009), Ueha et al. (2007) | ||
| CCR1 | + (1–3, 6) | + (1, 2, 3) | + (1, 2) | + (1, 2) | Bouazzaoui et al. (2009), Kittan and Hildebrandt (2010), Choi et al. (2007), Ueha et al. (2007) | |
| CCR2 | + (1) | + (1, 2) | + (2, 3) | + (3) | + (1, 2) | Bouazzaoui et al. (2009), Kittan and Hildebrandt (2010), Wysocki et al. (2005), Ueha et al. (2007), Terwey et al. (2005) |
| CCR4 | + (2) | Reiss et al. (2001) | ||||
| CCR5 | + (1) | + (1, 3, 6) | + (1, 2, 3) | + (2) | + (1, 2) | Bouazzaoui et al. (2009), Kittan and Hildebrandt (2010), Wysocki et al. (2005), Ueha et al. (2007), Murai et al. (1999) |
| CCR6 | + (1, 2, 3) | Varona et al. (2006) | ||||
| CCR10 | (1, 2) | Reiss et al. (2001) | ||||
| XCR1 | – | + (2, 3) | + (2, 3) | + (1, 2) | Bouazzaoui et al. (2009), Kittan and Hildebrandt (2010) | |
| CX3CR1 | + (1, 2) | Ueha et al. (2007) | ||||