Table 1.
Aging alters expression of cell cycle-related genes in response to oxidative stress
| A. Cell Cycle Arrest | ||||
|---|---|---|---|---|
| Gene name | Assession # | ΔO: ΔY | ΔY | ΔO |
| PLK3 | NM_013807 | −4.9 | 3.7 | |
| Gadd45g | NM_011817 | −4.4 | 6.0 | 1.4 |
| Gadd45b | NM_008655 | −4.3 | 2.0 | −2.1 |
| PAK3 | NM_008778 | −3.7 | 3.1 | −2.1 |
| Zpf346/Jaz | NM_012017 | −3.3 | 3.0 | |
| G0/G1 switch 2 | NM_008059 | −2.9 | 1.5 | |
| SNF1-like kinase | NM_010831 | −2.8 | 1.5 | −1.8 |
| Dot1-like | NM_199322 | −2.4 | −1.7 | |
| Cebpβ | NM_009883 | −2.2 | 2.0 | |
| Jund1 | NM_010592 | −1.7 | 1.3 | −1.3 |
| E2F6 | NM_033270 | −1.5 | ||
| B. Cell Cycle Progression | ||||
|---|---|---|---|---|
| Gene name | Assession # | ΔO: ΔY | ΔY | ΔO |
| RRM2 | NM_009104 | 2.8 | −2.5 | |
| Thymidine kinase | NM_009387 | 2.0 | −1.4 | 1.4 |
| RRM1 | NM_009103 | 1.9 | −1.3 | 1.4 |
| Kras2 | NM_021284 | 1.7 | −1.4 | 1.2 |
| BRCA2 | NM_009765 | 1.7 | 1.6 | |
| Ask/BBF4 | NM_013726 | 1.7 | ||
| Thioredoxin | NM_021284 | 1.6 | −1.2 | 1.2 |
| Cyclin H | NM_023243 | 1.5 | −1.4 | |
| DHFR | NM_010049 | 1.5 | 1.3 | |
| PCNA | NM_011045 | 1.4 | −1.3 | |
| Poldelta 2 | NM_008894 | 1.4 | 1.6 | |
The differential response to 2NP in old relative to young is presented as ΔO:ΔY. Additionally, response to 2NP in young (ΔY) and old (ΔO) are presented. All differences are significant at p<0.005.