Table 2.
Aging alters expression of genes involved in apoptosis following oxidative stress
| Accession# | Gene name | ΔO:ΔY | ΔY | ΔO | Role in Apoptosis |
|---|---|---|---|---|---|
| NM_007702 | Cidea | −5.4 | −5.1 | Activates apoptosis | |
| NM_178373 | Cidec | −4.5 | 1.6 | −2.8 | Promotes apoptosis |
| NM_011817 | Gadd45g | −4.4 | 6.0 | 1.4 | Strongly potentiates apoptosis; also cdc2/cyclinB1 kinase inhibitor |
| NM_008655 | Gadd45b | −4.3 | 2.0 | −2.1 | Effector of TGFbeta-induced apoptosis |
| NM_012017 | Zfp346 | −3.3 | 3.0 | Mediates apoptosis (and cell cycle arrest) as positive regulator of p53; alias, JAZ | |
| NM_013486 | Cd2 | −2.6 | Induces caspase-independent apoptosis | ||
| NM_009883 | Cebpb | −2.2 | 2.0 | Shown both to promote and inhibit apoptosis | |
| NM_009744 | Bcl6 | 2.1 | Anti-apoptotic | ||
| NM_010019 | Dapk2 | 2.2 | −2.5 | Pro-apoptotic | |
| NM_008764 | Tnfrsf11b | 2.2 | 1.5 | Anti- apoptotic | |
| NM_011415 | Slugh | 3.1 | −1.3 | 2.3 | Anti-apop totic |
The differential response to 2NP in old relative to young is presented as ΔO:ΔY. Additionally, response to 2NP in young (ΔY) and old (ΔO) are presented. All differences are significant at p<0.005.