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. 2012 Feb 24;2:285. doi: 10.1038/srep00285

Figure 5. CB1 receptor agonists reduce the amplitude of MF-GPSCs.

Figure 5

(A) The depressant effect of WIN 55,212-2 (2 μM, bar) on MF-GPSCs was occluded by subsequent pairing (arrow, n = 12). (B) When WIN 55,212-2 (bar) was applied after pairing (arrow) it did not affect MF-GPSCs (n = 8). (C) Individual samples (average of 30 to 60 responses including failures) from A and B respectively. (D) Mean MF-GPSCs amplitude obtained in all cells tested after application of WIN 55,212-2 (n = 17), AEA (n = 13) or AEA plus AM351 (n = 10). Note that AM251 completely antagonized the effects of AEA on MF-GPSCs. **p ≤ 0.01.