Skip to main content
. 2012 Mar;18(3):519–529. doi: 10.1261/rna.030346.111

FIGURE 1.

FIGURE 1.

Schematic representation of the 5′ UTR and frameshifting region of HIV-1 full-length mRNA. This mRNA is capped and polyadenylated. Its 5′ UTR is shown under the Weeks conformation, as adapted from Wilkinson et al. (2008). The regulatory motifs present in this region are indicated: the TAR stem–loop, the poly(A) stem–loop containing the polyadenylation signal, the primer binding site (PBS), the dimerization initiation site (DIS), the major splice donor site (SD), and the packaging signal (ψ). The IRES encompasses the region delineated by the dashed line. The AUG initiator codon of gag is boxed. The rest of the mRNA is represented by a thin line except for the HIV-1 frameshift region. The slippery sequence, UUUUUUA, where the frameshift takes place, is indicated, followed by the frameshift stimulatory signal (FSS). The gag coding region is delineated by the AUG initiator codon and the stop codon in the zero frame. The pol coding sequence is delineated by the slippery sequence and the stop codon in the −1 frame.