Table 2.

Continuous EEG monitoring yield and non-convulsive seizure yield by monitoring strategy.

Monitoring Strategy	A Number of patients meeting EEG monitoring indication during screening month	B % with non-convulsive seizures reported in literature	C Average number of patients with non-convulsive seizures C=B% of A	D Average EEG monitoring duration (days)	E Average EEG monitoring number of days E=A×D	F EEG Monitoring Yielda F=C/E	G Non-Convulsive Seizure Yieldb
Prolonged-Targeted	33	46%c	15.2	3.2d	106	0.14	100%c
Brief-Targeted	33	43%c	14.2	1e	33	0.43	94%c

^aEEG Monitoring Yield = Non-convulsive seizure patients detected per EEG monitoring day.

^bNon-convulsive seizure Yield = estimate of patients with non-convulsive seizures who would have non-convulsive seizures identified using this strategy based on published literature.

^cReference 3. 46% of children undergoing EEG monitoring have non-convulsive seizures, and 100% are detected with 72 hours of monitoring. 43% of children undergoing EEG monitoring have non-convulsive seizures detected in the first 24 hours of monitoring, indicating 94% of children with non-convulsive seizures could be identified with 24 hours of monitoring.

^dAverage duration of altered mental status from screening month data.

^eBy definition, EEG monitoring duration is one day for the brief-targeted strategy.