Table 6.
Diagnostic accuracy of simple fibrosis prediction tests for significant and extensive fibrosis
| Score | Cut-off value | (%) | Significant fibrosis (F2, F3 and F4) | Extensive fibrosis (F3 and F4) | ||||||
| Sen | Spe | PPV | NPV | Sen | Spe | PPV | NPV | |||
| FibroQ | > 0.6 | 94.9 | 96.4 | 12.2 | 84.0 | 41.7 | 97.3 | 7.14 | 48.0 | 75.0 |
| > 1.2 | 79.7 | 85.7 | 48.8 | 88.9 | 41.7 | 90.1 | 29.4 | 52.9 | 77.1 | |
| > 1.4 | 74.3 | 80.1 | 53.7 | 89.2 | 36.1 | 86.5 | 36.5 | 54.5 | 75.4 | |
| > 1.6 | 70.0 | 77.6 | 65.9 | 91.6 | 38.0 | 85.6 | 43.7 | 57.2 | 77.5 | |
| > 1.8 | 66.2 | 74.0 | 70.7 | 92.4 | 36.3 | 83.8 | 49.2 | 59.2 | 77.5 | |
| > 2.0 | 60.8 | 69.4 | 80.5 | 94.4 | 35.5 | 82.0 | 57.9 | 63.2 | 78.5 | |
| > 2.6 | 44.3 | 51.0 | 87.8 | 95.2 | 27.3 | 64.9 | 73.8 | 68.6 | 70.5 | |
| AAR | > 0.4 | 97.0 | 95.4 | 12.2 | 83.9 | 35.7 | 96.4 | 7.1 | 47.8 | 69.2 |
| > 0.6 | 61.2 | 67.9 | 70.7 | 91.7 | 31.5 | 77.5 | 53.2 | 59.3 | 72.8 | |
| > 0.8 | 28.7 | 31.6 | 85.4 | 91.2 | 20.7 | 36.9 | 78.6 | 60.3 | 58.6 | |
| > 1.0 | 6.8 | 8.16 | 100 | 100 | 18.5 | 10.8 | 96.8 | 75.0 | 55.2 | |
| APRI | > 0.5 | 95.8 | 96.9 | 9.7 | 83.7 | 40.0 | 99.1 | 7.1 | 48.5 | 90.0 |
| > 1 | 72.6 | 75.5 | 41.5 | 86.0 | 26.2 | 87.4 | 40.5 | 56.4 | 78.5 | |
| > 1.5 | 54.0 | 56.6 | 58.5 | 86.7 | 22.0 | 69.4 | 59.5 | 60.2 | 68.8 | |
| > 2 | 39.7 | 45.4 | 87.8 | 94.7 | 25.2 | 55.0 | 73.8 | 64.9 | 65.0 | |
| CDS | > 5 | 88.6 | 88.8 | 12.2 | 82.9 | 18.5 | 92.8 | 15.1 | 49.0 | 70.4 |
| > 6 | 63.7 | 66.3 | 48.8 | 86.1 | 23.3 | 73.9 | 45.2 | 54.3 | 66.3 | |
| > 7 | 29.1 | 30.6 | 78.0 | 87.0 | 19.0 | 34.2 | 75.4 | 55.1 | 56.5 | |
| > 8 | 8.9 | 9.7 | 95.1 | 90.5 | 18.1 | 12.6 | 94.4 | 66.7 | 55.1 | |
| API | > 4 | 75.9 | 81.6 | 51.2 | 88.9 | 36.8 | 87.4 | 34.1 | 53.9 | 75.4 |
| > 5 | 67.1 | 73.5 | 63.4 | 90.6 | 33.3 | 82.0 | 46.0 | 57.2 | 74.4 | |
| > 6 | 57.4 | 63.3 | 70.7 | 91.2 | 28.7 | 74.8 | 57.9 | 61.0 | 72.3 | |
| > 7 | 39.7 | 46.4 | 92.7 | 96.8 | 26.6 | 56.8 | 75.4 | 67.0 | 66.4 | |
| Pohl score | Positive | 3.8 | 4.59 | 100 | 100 | 18.0 | 7.2 | 99.2 | 88.9 | 54.8 |
| FIB-4 | > 1.45 | 75.5 | 81.6 | 53.7 | 89.4 | 37.9 | 87.4 | 34.9 | 54.2 | 75.9 |
| > 2 | 62.0 | 69.4 | 73.2 | 92.5 | 33.3 | 81.1 | 54.8 | 61.2 | 76.7 | |
| > 2.5 | 53.6 | 61.2 | 82.9 | 94.5 | 30.9 | 74.8 | 65.1 | 65.4 | 74.5 | |
| > 3 | 46.0 | 52.6 | 85.4 | 94.5 | 27.3 | 66.7 | 72.2 | 67.9 | 71.1 | |
| > 3.25 | 40.9 | 47.4 | 90.2 | 95.9 | 26.4 | 61.3 | 77.0 | 70.1 | 69.3 | |
| Lok’s model | > 0.2 | 74.7 | 81.6 | 58.5 | 90.4 | 40.4 | 88.3 | 37.3 | 55.4 | 78.3 |
| > 0.4 | 35.0 | 40.8 | 92.7 | 96.4 | 24.7 | 51.4 | 79.4 | 68.7 | 64.9 | |
| > 0.5 | 24.1 | 28.6 | 97.6 | 98.2 | 22.2 | 37.8 | 88.1 | 73.7 | 61.7 | |
AAR: AST/ALT ratio; APRI: AST-to-platelet ratio index; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; API: Age-platelet index; CDS: Cirrhosis discriminant score; Sen: Sensitivity; Spe: Specificity; PPV: Positive predictive value; NPV: Negative predictive value.