Table 4.

PSA and biomarkers of angiogenesis and inflammation compared after 12 weeks on study

The treated group received 12 weeks of androgen deprivation therapy with a gonadotropin-releasing hormone agonist whereas the control group did not receive therapy for prostate cancer. Plasma cytokine levels are shown in pg/mL. Values are reported as median (interquartile range). p-values are for comparisons of treatment and control groups using the Wilcoxon exact test.

Abbreviations: bFGF, basic fibroblast growth factor; CRP, C-reactive protein; IL, interleukin; PlGF, placental growth factor; PSA, prostate-specific antigen; SAA, serum amyloid A; SDF-1α, stromal cell–derived factor 1α; sICAM-1, soluble intercellular adhesion molecule 1; sVCAM-1, soluble vascular cell adhesion molecule 1; sVEGFR, soluble VEGF receptor; TNF-α, tumor necrosis factor α; VEGF, vascular endothelial growth factor.