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. 2011 Dec 7;119(6):1511–1521. doi: 10.1182/blood-2011-02-338210

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© 2012 by The American Society of Hematology

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Lineage contribution of KIT-transduced bone marrow cells in transplanted mice. PB cells were collected at the indicated times after transplantation from the recipient mice, stained for the indicated markers, and analyzed by FACS. (A) WT BM cells transduced with GFP. (B) WT BM cells transduced with KIT^D816. (C) Cbfb^+/56m; Tg(Mx1-Cre) BM cells transduced with GFP. (D) Cbfb^+/56m; Tg(Mx1-Cre) BM cells transduced with KIT^D816Y. (E) PB from a mouse that was starting to develop leukemia that was transplanted with Cbfb^+/56m; Tg(Mx1-Cre) BM cells expressing KIT^D816Y. CD3/4/8 indicates combination staining of CD3, CD4, and CD8.