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Comparison of pharmacokinetics of DIG during the pretreatment (control) phase of study 1 (n = 16) and study 2 (n = 9, 24 h after bupropion administration). Administration of bupropion 24 h before DIG did not significantly affect DIG Cmax (A), Tmax (B), or AUC0–4 h (C) but significantly decreased AUC0–24 h (D) and significantly increased DIG Clrenal (E).
