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. 2012 Mar;40(3):426–435. doi: 10.1124/dmd.111.042739

Fig. 1.

Fig. 1.

Inhibition of CYP3A4 by trans-ITZ stereoisomers. IC50 inhibition of CYP3A4 by trans-ITZs (2R,4R,2′R in A; 2R,4R,2′S in B; 2S,4S,2′S in C; and 2S,4S,2′R in D) in human liver microsomes using midazolam as the probe substrate. IC50 was determined by fitting eq. 1 to the data.