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. 2012 Mar;40(3):596–601. doi: 10.1124/dmd.111.043679

Fig. 7.

Fig. 7.

Formation of NAC-BDA-NAL was significantly inhibited by CYP2E1 but not CYP3A4 or CYP2D6 inhibitors. A, results obtained with human liver microsomal preparation 8 in which 50 μM furan was incubated with 200 μM 1-phenylimidazole (PI), 2 μM ketoconazole (Keto), or 5 μM quinidine (Quin) in the presence of NAC, NAL, and an NADPH-regenerating system. B, results obtained with human liver microsomal preparation 3 in which 50 μM furan was incubated with 5 μM 1-phenylimidazole (PI), 50 μM 4-methylpyrazole (MP), or 20 μM diethyldithiocarbamate (DDC) in the presence of NAC, NAL, and an NADPH-regenerating system.