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Docking scores for PC2 inhibitors at different binding sites.
| Compound | Active site | Allosteric Site 1 | Allosteric Site 3 | Type of Inhibition | Ki |
|---|---|---|---|---|---|
| kcal/mol | μM | ||||
| 166830 | −5.9 | −6.7 | −6.6 | Competitive | 2.1 ± 0.2 |
| 166829 | −5.3 | −6.3 | −9.0 | Noncompetitive | 11.7 ± 1.1 |
| 166369 | −9.0 | −9.8 | −8.9 | Mixed | 7.3 ± 2.3 |
