TABLE 1.
IC50 values for antiproliferative activities of polygamain, podophyllotoxin, and CA-4 against diverse cancer cell lines
| Cell Line | Polygamain IC50 | Rr | Podophyllotoxin IC50 | Rr | CA-4 IC50 | Rr |
|---|---|---|---|---|---|---|
| nM | nM | nM | ||||
| MDA-MB-435 | 26.3 ± 2.5 | 5.7 ± 0.5 | 2.4 ± 0.1 | |||
| DU 145 | 54.9 ± 4.6 | 9.4 ± 1.0 | 5.3 ± 0.3 | |||
| PC-3 | 70.6 ± 2.6 | 16.1 ± 1.3 | 7.9 ± 0.6 | |||
| SCC-4 | 36.4 ± 2.0 | 14.5 ± 0.5 | 7.3 ± 0.9 | |||
| A549 | 65.8 ± 3.7 | 9.8 ± 0.9 | 5.9 ± 0.5 | |||
| MDA-MB-231 | 78.2 ± 5.4 | 13.6 ± 1.0 | 7.3 ± 0.3 | |||
| HeLa | 37.9 ± 1.9 | 8.4 ± 0.5 | 3.5 ± 0.4 | |||
| WTβIII | 36.9 ± 1.5 | 1.0 | 9.1 ± 0.6 | 1.1 | 3.7 ± 0.8 | 1.1 |
| SK-OV-3 | 51.3 ± 2.1 | 7.5 ± 0.2 | 4.4 ± 0.4 | |||
| SK-OV-3-MDR-1-6/6 | 102.1 ± 1.9 | 2.0 | 47.5 ± 2.5 | 6.3 | 32.4 ± 7.4 | 7.4 |