Fig. 5.
Effect of cyclothiazide on quisqualic acid- and AMPA-induced dystonia. A, cyclothiazide dose-dependently promoted quisqualic acid-induced dystonia (one-way ANOVA: F3,25 = 3.9, p < 0.05, n = 6–8/dose). B, cyclothiazide dose-dependently potentiated (S)-AMPA-induced dystonia (one-way ANOVA: F3,22 = 3.4, p < 0.05, n = 6–7/dose). Disability scores lower than 10 (dashed lines) suggest abnormal motor behavior, such as an unsteady gait, but not overt dystonia. Values represent the mean of the cumulative disability score in 1 h ± S.E.M.; **, p < 0.01 compared with vehicle.