TABLE 3.
Summary of behavioral findings in adult animals exposed as neonates to antiepileptic drugs
| Treatment | Elevated Plus Maze | Cued Fear Conditioning | Contextual Fear Conditioning | Prepulse Inhibition | Social Behavior | Rotorod | Morris Water Maze | Open Field |
|---|---|---|---|---|---|---|---|---|
| Phenobarbital | Decreased anxiety-like behavior | Decreased learning/memory | No change | Decreased sensorimotor gating | Decreased social exploration | No change | Impaired learning | No change |
| Phenytoin | No change | Decreased learning/memory | No change | No change | Decreased social exploration | Decreased peak performance | Impaired learning | Decreased exploration of center |
| Lamotrigine | No change | No change | No change | No change | Decreased social exploration | Decreased peak performance | Impaired learning | No change |