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. 2012 Mar;340(3):558–566. doi: 10.1124/jpet.111.188862

TABLE 3.

Summary of behavioral findings in adult animals exposed as neonates to antiepileptic drugs

Treatment Elevated Plus Maze Cued Fear Conditioning Contextual Fear Conditioning Prepulse Inhibition Social Behavior Rotorod Morris Water Maze Open Field
Phenobarbital Decreased anxiety-like behavior Decreased learning/memory No change Decreased sensorimotor gating Decreased social exploration No change Impaired learning No change
Phenytoin No change Decreased learning/memory No change No change Decreased social exploration Decreased peak performance Impaired learning Decreased exploration of center
Lamotrigine No change No change No change No change Decreased social exploration Decreased peak performance Impaired learning No change