Figure 3.
Neuroimaging on illustrative Family member 3. MRI at the age of 54 (A). Top: T1 axial images at the level of hippocampus (left) and corona radiata (right), demonstrating anterior frontal and temporal lobar atrophy (left > right). Bottom: T2 coronal images at the level of the hippocampus (left) and cerebellum (right), further demonstrating the asymmetric atrophy and showing hippocampal atrophy that is mild compared to the degree of cortical involvement. FDG-PET at the age of 54 years (B) shows hypometabolism in the frontal lobes relative to the occipital cortex at the level of the basal ganglia (left) and the cerebellum (right).