Table 5.
Evolution of clinical features of study subjects
| Domain Symptoms | n (%) affected in first year | n (%) affected in final year |
|---|---|---|
| Behaviour | 14 (47) | 25 (83) |
| Disinhibition | 12 (40) | 21 (70) |
| Decline in self-care | 6 (20) | 22 (73) |
| Rigidity/perseveration | 8 (27) | 15 (50) |
| Affect | 12 (40) | 20 (67) |
| Apathy | 9 (30) | 14 (47) |
| Depression | 4 (13) | 7 (23) |
| Executive | 12 (40) | 24 (80) |
| Planning/set shifting | 12 (40) | 22 (73) |
| Impaired abstraction | 10 (33) | 17 (57) |
| Poor judgement | 8 (27) | 21 (70) |
| Poor attention | 6 (20) | 12 (40) |
| Language | 14 (47) | 23 (77) |
| Reduced fluency | 12 (40) | 21 (70) |
| Word finding difficulty | 10 (33) | 17 (57) |
| Fluent aphasia | 0 (0) | 0 (0) |
| Memory (short-term) | 9 (30) | 18 (60) |
| Visuospatial | 3 (10) | 8 (27) |
| Apraxia | 1 (3) | 4 (13) |
| Extrapyramidal signs | 3 (10) | 12 (40) |
| Rigidity/bradykinesia | 2 (7) | 9 (30) |
| Tremor | 1 (3) | 4 (13) |
| ALS features | 10 (33) | 15 (50) |
| Upper motor neuron dysfunction | 7 (23) | 15 (50) |
| Lower motor neuron dysfunction | 5 (17) | 14 (47) |
| Bulbar dysfunction | 2 (7) | 14 (47) |