Skip to main content
. 2012 Feb 24;135(3):765–783. doi: 10.1093/brain/aws004

Figure 5.

Figure 5

Microscopic findings of c9FTD/ALS. Ubiquitin immunohistochemistry (A) compared with phospho-TDP-43 immunohistochemistry (B) in adjacent sections of dentate fascia of hippocampus (Kindred 14, Case 1.III.1). Note considerably more neuronal inclusions and neurites with ubiquitin. Ubiquitin-positive cerebellar inclusions in same case at lower magnification (C) and higher magnification (D). Frontal cortex phospho-TDP-43 immunohistochemistry: type A in Patient III.1 from Kindred 5 shows short neurites, neuronal inclusions and intranuclear inclusions (inset); and type B in Patient IV.1 from Kindred 12 shows mostly neuronal inclusions, including so-called ‘pre-inclusions’. Scale bar = 30 μm for A–C, E and F and 6 μm for D and E inset.