Table 4.

Expression of genes related to reactive oxygen species production and oxidative defence as well as genes induced by oxidative stress in initial multiple sclerosis lesions (>2 log₂-fold changed expression values in at least one of three patients)

	Upregulated	Downregulated
Reactive oxygen species production	CYBA, CYBB, NCF1 MPO, EPX, PTGS1, PXDN	NOS1, NOS2A, NOS3, NOX5, MIOX, RAC1, RAC3,
Reactive oxygen species detoxification	GPX4, PRDX1, 2, 4	GPX3, GPX5, PRDX3
Induced by reactive oxygen species	ALOX12, ATOX1, EPHX2, GPR156, MSRA, STK25, OSGIN, GLRX2, PRG3, SEPP1, SGK2, TXNRD2	APOE, CYGB, PNKP, SCARA3, SFTPD, SIRT2, SRXN1

This table lists genes that are involved in production or detoxification of reactive oxygen species or are induced by oxidative stress and are up- or downregulated (>2 log₂-fold) in initial multiple sclerosis lesions. Gene abbreviations and function can be found at www.ihop-net.org and www.sigmaaldrich.com/customer-services/services/basic-research.htlm.