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. 2011 Dec 14;119(7):1693–1701. doi: 10.1182/blood-2011-05-357319

Figure 4.

Figure 4

Impaired maturation of Rras−/− BM-DC. (A) BM-DCs in culture for 6 days from Rras+/+ (n = 3) and Rras−/− mice (n = 3) in 129Sv strain were treated without (opened areas) or with (shaded areas) LPS (0.1 μg/mL) for 12 hours. Maturation markers were plotted as histograms on CD11c+ gated cells. MFI values are quantified in the bottom panels. Bars represent SE. ***P < .0005. *P < .05. Similar results were reproduced in an independent experiment (supplemental Figure 3A). (B) Rras+/+ (n = 3) and Rras−/− (n = 3) mice were intraperitoneally injected with 10 μg LPS (0.45 mg/kg). After 6 to 8 hours, the levels of maturation markers were analyzed on CD11c+ gated cells as described in panel A. Bars represent SE. *P < .05. Similar results were obtained in at least 2 independent experiments (supplemental Figure 3C).