Table 1.
Prevalence of features of metabolic syndrome at baseline in patients assigned to placebo in the FIELD study (points of difference in criteria are shown in bold)
| Feature of metabolic syndrome | Men | Women | All patients |
|---|---|---|---|
| (n = 3067) | (n = 1833) | (n = 4900) | |
| ATPIII criteria (any 3) | |||
| Diabetes or impaired fasting glucose | 100 | 100 | 100 |
| High waist measurement (M > 102 cm, F > 88 cm) | 54.5 | 80.6 | 64.3 |
| Hypertension history or BP ≥ 130/85 mmHg | 82.2 | 85.8 | 83.6 |
| High triglycerides (≥ 1.7 mmol/L) | 50.0 | 54.1 | 51.5 |
| Low HDL cholesterol (M < 1.03 mmol/L, F < 1.29 mmol/L) | 54.8 | 66.2 | 59.1 |
| Metabolic syndrome according to ATPIII | 78.3 | 90.3 | 82.8 |
| IDF criteria (waist + any 2) | |||
| Diabetes or impaired fasting glucose | 100 | 100 | 100 |
| High waist measurement (M ≥ 94 cm, F ≥ 80 cm) | 83.9 | 95.0 | 88.0 |
| Hypertension history or BP ≥ 130/85 mmHg | 82.2 | 85.8 | 83.6 |
| High triglycerides (≥ 1.7 mmol/L) | 50.0 | 54.1 | 51.5 |
| Low HDL cholesterol (M < 1.03 mmol/L, F < 1.29 mmol/L) | 54.8 | 66.2 | 59.1 |
| Metabolic syndrome according to IDF | 80.5 | 92.5 | 85.0 |
| Harmonized criteria (any 3) | |||
| Diabetes or impaired fasting glucose | 100 | 100 | 100 |
| High waist measurement (M ≥ 94 cm, F ≥ 80 cm) | 83.9 | 95.0 | 88.0 |
| Hypertension history or BP ≥ 130/85 mmHg | 82.2 | 85.8 | 83.6 |
| High triglycerides (≥ 1.7 mmol/L) | 50.0 | 54.1 | 51.5 |
| Low HDL cholesterol (M < 1.03 mmol/L, F < 1.29 mmol/L) | 54.8 | 66.2 | 59.1 |
| Metabolic syndrome according to harmonized definition | 87.6 | 94.7 | 90.3 |
| WHO criteria (diabetes + any 2) | |||
| Diabetes or impaired fasting glucose | 100 | 100 | 100 |
| High waist-hip ratio (M > 0.9, F > 0.85) or BMI > 30 | 88.5 | 80.5 | 85.5 |
| Hypertension history or blood pressure ≥ 140/90 mmHg | 68.5 | 73.3 | 70.3 |
| High triglycerides (≥ 1.7 mmol/L) and/or low HDL-c (M < 0.9 mmol/L, F < 1.0 mmol/L) | 58.9 | 59.0 | 58.9 |
| Microalbuminuria (urine albumin/creatinine ≥ 3.4 mg/mmol) | 23.6 | 20.8 | 22.6 |
| Metabolic syndrome according to WHO | 82.6 | 80.7 | 81.9 |
* IDF criteria for hypertension, high triglyceride, and low HDL-c are the same as those for ATPIII.
† Harmonized criteria are the same as for IDF except metabolic syndrome does not require high waist measurement.
‡ Ethnic and sex-specific cut-offs for waist circumference define high risk in the harmonized definition. This analysis, for a population mainly of European origin, used the "Caucasian" waist cut-off.
FIELD, Fenofibrate Intervention and Event Lowering in Diabetes; ATPIII, Adult Treatment Panel III; M, male; F, female; BP, blood pressure; IDF, International Diabetes Federation; WHO, World Health Organization; HDL-c, high-density lipoprotein cholesterol