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HIV-1 integrase mutants. (A) Crystal structure of an INNTD-CCD tetramer ABCD (PDB ID 1k6y, [89]) represented in ribbons. Individual subunits of IN are colored blue, cyan, red, and gold. (B) At the NTD-CCD interface, the ε-amine of Lys188 is located at 2.8 Å from Asp25 making and H-bond and at 4.5 Å from Glu198 (also indicated). (C) INCCD LEDGF/p75IBD interface (PDB ID 2b4j, [24]). Individual subunits of IN are colored in blue and cyan, LEDGF/p75IBD is colored in grey.
