Table 2. Association of Helicobacter pylori (H. pylori) seropositivity with risk of lung adenocarcinoma and squamous cell carcinoma in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study.
| Model | H. pylori serostatus | Histology | Cases, N* (%) | Controls, N* (%) | OR (95% CI)† |
| 1 | H. pylori seronegative | Adenocarcinoma | 74 (21.2) | 79 (22.8) | 1.0 (referent) |
| H. pylori seropositive | 275 (78.8) | 268 (77.2) | 1.1 (0.75–1.6) | ||
| 2‡ | H. pylori seronegative | 74 (21.2) | 79 (22.8) | 1.0 (referent) | |
| CagA-seronegative‡ | 125 (35.8) | 119 (34.3) | 1.1 (0.71–1.7) | ||
| CagA-seropositive‡ | 150 (43.0) | 149 (42.9) | 1.1 (0.73–1.7) | ||
| 1 | H. pylori seronegative | Squamous cell carcinoma | 67 (19.3) | 70 (20.2) | 1.0 (referent) |
| H. pylori seropositive | 280 (80.7) | 276 (79.8) | 1.1 (0.77–1.7) | ||
| 2‡ | H. pylori seronegative | 67 (19.3) | 70 (20.2) | 1.0 (referent) | |
| CagA-seronegative ‡ | 133 (38.3) | 119 (34.4) | 1.3 (0.82–1.9) | ||
| CagA-seropositive ‡ | 147 (42.4) | 157 (45.4) | 1.0 (0.65–1.6) | ||
| 1 | H. pylori seronegative | All lung cancer | 141 (20.3) | 149 (21.5) | 1.0 (referent) |
| H. pylori seropositive | 555 (79.7) | 544 (78.5) | 1.1 (0.86–1.5) | ||
| 2‡ | H. pylori seronegative | 141 (20.3) | 149 (21.5) | 1.0 (referent) | |
| CagA-seronegative ‡ | 258 (37.1) | 238 (34.3) | 1.2 (0.87–1.6) | ||
| CagA-seropositive ‡ | 297 (42.7) | 306 (44.2) | 1.1 (0.79–1.5) |
*N's do not sum to total due to missing values.
†
Odds ratios (ORs) and 95% confidence intervals (CIs) were adjusted for baseline pack-years and total number of cigarettes per day.
‡
Single model for CagA-seropositive and CagA-seronegative versus no H. pylori seropositivity.