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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Nat Rev Microbiol. 2011 Aug 8;9(10):713–723. doi: 10.1038/nrmicro2622

Figure 3.

Figure 3

(A) Adiantum capillus-veneris phy3(neochrome)-LOV2 domain in the illuminated state (PDB code: 1JNU). α-helices are colored in blue; β-strands in yellow; loops in green. The FMN cofactor is colored in light gray. Helix Eα is shown as transparent to reveal the cysteinyl-FMN adduct. (B) Flavin-binding pocket of phy3-LOV2 domain. Residues that interact with the FMN cofactor are shown for the illuminated state (PDB code: 1JNU) (in orange), and for the dark state (PDB code: 1G28) (in gray). The glutamine (Q1029) of strand Hβ that rotates 180° on light activation is labeled as is the cysteine that forms the cysteinyl-FMN adduct (C966). (C) Schematic of cysteinyl-C(4a) covalent adduct formation in response to light absorption by the LOV domain.

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