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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Bioorg Med Chem Lett. 2011 Feb 2;21(7):2129–2132. doi: 10.1016/j.bmcl.2011.01.128

Table 1.

Catalytic activity and acetate inhibition constant of wild-type and mutant HDAC8a

HDAC8 kcat/Km (M-1s-1) IC50, Acetate (mM)
Co(II)-WT 7400 ± 100 2.5 ± 0.3
Co(II)-R37A 14 ± 1 400 ± 60
Co(II)-R37E 0.19 ± 0.04 ndb
a

Measured in 25 mM Tris pH 8.0, 137 mM NaCl and 2.7 mM KCl.

b

Not determined