Table 1.
Effect of single dose (50 mg/kg bw) administration of GII compound on FBG and GTT in the subdiabetic and moderately diabetic rabbits
| Diabetic status | Plasma glucose mg/dl | |||
|---|---|---|---|---|
| Fasting | 1 h | 2.5 h | AUC | |
| Normal | 90.1 ± 3 | 148.2 ± 5 | 134.6 ± 4 | 20,160 |
| Subdiabetic untreated | 96.1 ± 4 | 296.6 ± 5 | 270.0 ± 9 | 37,230 |
| Subdiabetic treated | 92.7 ± 4 | 220.7 ± 7 | 200.2 ± 4 | 28,260 |
| Change after treatment | −4% | −25% | −26% | −24% |
| NS | P < 0.01 | P < 0.01 | ||
| Moderately diabetic untreated | 150.4 ± 15 | 286.0 ± 18 | 189.1 ± 8 | 34,700 |
| Moderately diabetic treated | 147.3 ± 9 | 196.0 ± 7 | 170.2 ± 9 | 26,730 |
| Change after treatment | −2% | −34% | −10% | −21% |
| NS | P < 0.01 | P < 0.01 | ||
AUC Area under the curve of GTT, NS Not significant