Table 2.
Effect of GII compound on the FBG and GTT in the subdiabetic, moderately diabetic and severely diabetic rabbits
| Diabetic status | Plasma glucose mg/dl | |||
|---|---|---|---|---|
| Fasting | 1 h | 2.5 h | AUC | |
| Normal | 90.1 ± 3 | 148.2 ± 5 | 134.6 ± 4 | 20,160 |
| Subdiabetic day 0 | 96.6 ± 7 | 296.6 ± 38 | 270.7 ± 22 | 37,230 |
| Subdiabetic day 12 | 86.6 ± 6 | 146.1 ± 11 | 138.2 ± 9 | 19,740 |
| Percent change from day 0 | −10% | −50% | −48% | −47% |
| Moderately diabetic day 0 | 156.1 ± 14 | 286.6 ± 39 | 187.1 ± 13 | 31,410 |
| Moderately diabetic day 15 | 89.5 ± 5 | 148.6 ± 12 | 110.1 ± 8 | 19,350 |
| Percent change from day 0 | −40% | −48% | −41% | −38% |
| Severely diabetic day 0 | 427.8 ± 46 | GTT was not done in the severely diabetic rabbits because some animals die if glucose is given | ||
| Severely diabetic day 29 | 110.1 ± 11 | |||
| Percent change from day 0 | −75% | |||